Malaysian Airlines tweeted that "MAS has lost contact with MH17 from Amsterdam. The last known position was over Ukraine airspace.
A Malaysia Airlines Boeing 777 plane en route from Amsterdam to Kuala Lumpur has reportedly crashed in Ukraine near Russian border.
The plane, MH17, has 280 passengers and 15 crew on board, reports said. Reports said that it crashed in a conflicted area near Donetsk and it would be complicated to get to the crash.
MAS sources said the plane did not enter the Russian airspace. Sources said the plane was "shot down" while it was cruising at an altitude of 30,000ft.
Ukraine Interior Ministry said 295 people are feared dead in the crash. The plane could have been brought down by ground-to-air missile, sources said.