
The Airbus A330-200, flight number AF 447, left Rio de Janeiro for Paris, but radio contact was lost with the plane shortly after 0600 GMT, the reports said.
French President Nicolas Sarkozy is "greatly concerned" about the situation, according to his office, and a special crisis team and facilities have been set up at Paris' Charles de Gaulle airport - where the plane had been due to land at 09.10 GMT.
The Brazilian air force has now scrambled a search and rescue mission to the area around the tiny island of Fernando de Noronha, around 300 kilometres off the north east coast of Brazil.
French RTL broadcaster quoted Brazilian air traffic controllers as saying there had been no distress message from the plane.
According to Brazilian broadcaster Globonews, there were 216 passengers, and 12 crew on board.