
His replacement will be nursery team coach Manolo Zambrano until the end of the season in May.
Huelva are second from bottom in La Liga. The final nail in the coffin of Munoz was Sunday's 2-1 defeat at home to Sevilla.
Huelva - who claim to be the oldest club in Spain - are the fourth Liga side to sack their coach this season, following the example of fellow strugglers Betis, Levante and Valencia.
DPA