
The Aussie, an ex-number one now standing 21st, faced little opposition as he put down Argentine Jose Acasuso 6-2, 6-2. He next plays French sixth seed Jo-Wilfred Tsonga, who eliminated Ernests Gulbis of Latvia 6-3, 6-2.
Hewitt, now based in Sydney, has a massive history at Memorial Drive, where he got his start in the pro game. He captured his first ATP title 10 years ago at the age of 16 and then two years later; he also was a runner-up in 1999.
Acasuso won their last meeting in five sets in September, 2006, in Davis Cup semi-finals.
Hewitt's home win polished his recording Adelaide to 22-5 and puts him into the quarters or better for the sixth time in eight appearances.
Hewitt lost just three points in the first four games as he raced to a 4-0 lead before closing out the set on an ace.
Hewitt again dominated in the seconds set, breaking fifth and seventh games to seal victory in 61 minutes.
"It was good," Hewitt said of his aggressive attacking new style. "He's such a dangerous opponent and if you play into his hands he can really dictate play.
"It was a matter of me stepping up to the plate tonight and going after him."
In other second-round contests on a sweltering summer day, American Vincent Spadea, aged 33, reached the last eight 6-3 7-5 win over Germany's Mischa Zverev.
He next faces Finnish third seed Jarkko Nieminen, who improved to 4-0 over Canadian qualifier Frank Dancevic 6-4, 6-1.