
Ramos' resignation is almost certainly the prelude to him being appointed as coach of Premier League club Tottenham Hotspurs, who on Thursday night sacked Martin Jol.
Sevilla have not offered any details about Ramos' departure, or about the compensation that Tottenham might pay them, though it was clear that they are annoyed at the way their coach is walking out.
Neither have they announced who his replacement will be, although the Spanish media speculated that nursery team coach Manuel Jimenez will take charge on a caretaker basis.
Ramos, 53, has allegedly been offered a four-year contract by Tottenham worth around 7 million euros per season (10 million dollars). He has so far not made any statement about his departure.
Ramos has been the most successful coach in Sevilla's 102-year history, taking them to two UEFA Cups, one European Supercup and one Spanish King's Cup.