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Soe Win, who returned to Burma on Monday from a secret medical treatment in Singapore, died at about 5:00 p.m (local time), Mizzima News online quoted sources as saying.

The Burmese Prime Minister is known to have been suffering from Leukemia and had secretly received medical treatment in Singapore.

Soe Win, who is a Senior General Than Shwe loyalist, is also known as "the

Butcher of Depayin" for orchestrating the Depayin massacre in 2003 by ordering mobs to attack on pro-democracy leader Daw Aung San Suu Kyi's motorcade.

Sources said Soe Win will be replaced by Lt-Gen Thein Sein and Tin Aung Myint Oo will be promoted to Thein Sein's position as Secretary-I.