They said Thaksin has done nothing to tackle the problems but instead worsened the situation with his negative comments.
The calls were issued at the joint meeting of 43 networks of academicians of Chulalongkorn University on Saturday.
"We want to recommend that Thaksin resign and take a break from politics immediately to end the country's crisis. After Thaksin resigns, authorities concerned should be allowed to investigate allegations against the premier," said Dr Anand Loalartvorakul, a lecturer of Chulalongkorn University's Faculty of Arts.
They also called for government officials to realise that they do not have to serve corrupt government. They should defy any illegitimate rules from such government," he said.
People should not pay respect or "wai" to dishonest leaders. Anand said people should instead let those politicians know about that they were not wanted anymore wherever they go.
The networks will conduct more campaigns against Thaksin, he said, but they would be in peaceful ways. "We want to see fast and immediate changes on the matters, but we would not adopt violent ways for sure."